SUMO ylation promotes protective responses to DNA ‐protein crosslinks
نویسندگان
چکیده
منابع مشابه
Differential sensitivity of chromium-mediated DNA interstrand crosslinks and DNA-protein crosslinks to disruption by alkali and EDTA.
Some compounds of hexavalent chromium are well-established carcinogens. Chromium enters mammalian cells in the hexavalent form and is reduced to chromium (III). Treatment of purified DNA with chromium (III) produces DNA-DNA interstrand crosslinks (DDC) which obstruct the progression of DNA polymerases in vitro. DDC were also detected in chromate-treated cultured normal human lung cells using th...
متن کاملHigh-LET irradiation of a DNA-binding protein: protein-protein and DNA-protein crosslinks.
The chromosomal protein MC1 is a monomeric protein of 93 amino acids that is able to bind any DNA but has a slight preferential affinity for some sequences and structures, like cruciform and minicircles. The protein has been irradiated with 36Ar18+ ions of 95 MeV/nucleon. The LET of these particles in water is close to 270 keV/microm. We tested the activity of the protein by measuring its abili...
متن کاملPolycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a.
The 'de novo methyltransferase' Dnmt3a (DNA methyltransferase 3a) has been shown to mediate transcriptional repression. Post-translational modification of Dnmt3a by SUMOylation affects its ability to transcriptionally repress. However, very little is known about how the SUMOylation process is regulated. In the present study, we identified a PcG (Polycomb group) protein, Cbx4 (chromobox 4), as a...
متن کاملThe colibactin warhead crosslinks DNA
Members of the human microbiota are increasingly being correlated to human health and disease states, but the majority of the underlying microbial metabolites that regulate host-microbe interactions remain largely unexplored. Select strains of Escherichia coli present in the human colon have been linked to the initiation of inflammation-induced colorectal cancer through an unknown small-molecul...
متن کاملDNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses.
It is a testimony to the complexity of cancer that cytotoxic drugs are still a mainstay of therapeutic approaches to treat that disease. Perhaps even more paradoxical is the fact that cytotoxic therapy has its origin in the highly toxic mustard gas, which was developed for chemical warfare in the First World War. As with other crosslinking agents, such as mitomycin C, the chloroethylnitroso ure...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2019
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.2019101496